Sexual Health & NeuroendocrineIn StockSexual Health & Neuroendocrine
Melanotan II
Also known as: MT-2
Cyclic lactam heptapeptide α-MSH analog with broad melanocortin receptor activity (MC1R/MC3R/MC4R/MC5R).
Melanotan II (MT-2) is a cyclic lactam heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH).
It was developed at the University of Arizona as a research tool to study non-selective melanocortin-receptor pharmacology, with activity spanning MC1R, MC3R, MC4R, and MC5R.Unlike the more selective PT-141 (bremelanotide), which was derived from MT-II by removing the α-MSH segment responsible for MC1R activity, Melanotan II retains broad melanocortin-receptor activity including skin pigmentation (MC1R), feeding behavior and weight regulation (MC4R), and sexual-behavior signaling (MC3R/MC4R).Melanotan II has an extensive research literature spanning structural biology (its lactam-bridge design was influential in cyclic peptide drug development), metabolic signaling, pigmentation pathways, and behavioral neuroscience.
Research applications
- Non-selective melanocortin-receptor pharmacology
- Cyclic-peptide structure-activity relationships
- MC1R pigmentation and MC4R metabolic pathways
- Behavioral-neuroscience melanocortin research
- Comparative biology with PT-141 (selective variant)
Technical profile
- Net content
- 10 mg
- Molecular formula
- C50H69N15O9
- Molecular weight
- 1024.18 g/mol
- CAS
- 121062-08-6
- Sequence
- Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
Melanotan II is a cyclic heptapeptide analogue of α-MSH with broad melanocortin receptor activity. Research applications include skin pigmentation, appetite regulation, and sexual function studies due to its action on MC1R, MC3R, and MC4R receptors.
