Sexual Health & NeuroendocrineIn StockSexual Health & Neuroendocrine
Melanotan I
Also known as: MT-1, Afamelanotide, Scenesse (parent drug)
Synthetic 13-amino-acid α-MSH analog used in melanocortin-receptor pharmacology and pigmentation research.
Melanotan I (afamelanotide) is a synthetic 13-amino-acid analog of α-melanocyte-stimulating hormone (α-MSH), modified at position 4 (Met → Nle) and with a D-Phe substitution at position 7.
These modifications enhance stability and activity at melanocortin receptors, particularly MC1R.The parent pharmaceutical (Scenesse, Clinuvel Pharmaceuticals) is approved in the EU and the United States for a specific rare-disease indication related to erythropoietic protoporphyria.
This catalog entry refers to research-grade material for in-vitro investigation of melanocortin-receptor pharmacology.In the research literature, Melanotan I is used to probe MC1R-biased melanocortin signaling, pigmentation-pathway research (melanogenesis, eumelanin synthesis), and photoprotective-signaling models.
Research applications
- MC1R-biased melanocortin-receptor pharmacology
- Melanogenesis and eumelanin-synthesis research
- Photoprotective-signaling studies
- Comparative melanocortin-analog biology
- Peptide-stability research (Nle/D-Phe substitutions)
Technical profile
- Net content
- 10 mg
- Molecular formula
- C78H111N21O19
- Molecular weight
- 1646.85 g/mol
- CAS
- 75921-69-6
- Sequence
- Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
Melanotan I is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). It acts on melanocortin receptors to stimulate melanogenesis, increasing skin pigmentation and offering potential photoprotective benefits in research models.
