Longevity & Cellular HealthIn StockLongevity & Cellular Health
MOTS-C
Also known as: Mitochondrial-Derived Peptide, 12S rRNA-c
Endogenous 16-amino-acid mitochondrial-derived peptide encoded within the 12S ribosomal RNA region.
MOTS-c is a naturally occurring peptide encoded by a short open reading frame within the 12S ribosomal RNA region of mitochondrial DNA.
It was identified and characterized by the Cohen laboratory at USC and described in a series of publications beginning in 2015 as part of a broader family of mitochondrial-derived peptides (MDPs).Research on MOTS-c focuses on its roles in metabolic regulation, AMPK signaling, insulin-sensitivity research in animal models, and exercise physiology.
It is one of the newer additions to the longevity-peptide research toolkit, and its catalog presence has grown steadily across mid-tier suppliers since 2022.MOTS-c is supplied by Novera as lyophilized research-grade powder for in-vitro laboratory investigation.
Research applications
- Mitochondrial-derived peptide (MDP) biology
- AMPK signaling pathway research
- Insulin-sensitivity and metabolic-regulation studies
- Exercise-physiology research
- Aging and metabolic-health endpoints
Technical profile
- Net content
- 10 mg
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.64 g/mol
- CAS
- N/A
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
MOTS-C is a mitochondrial-derived peptide encoded within the 12S rRNA gene. It regulates metabolic homeostasis by activating AMPK pathways, improving insulin sensitivity, and promoting exercise-mimetic effects at the cellular level.
