Cognitive & NeuroprotectiveIn StockCognitive & Neuroprotective
PE-22-28
Also known as: Spadin analog
Synthetic 7-amino-acid fragment of the endogenous peptide spadin; studied in TREK-1 potassium channel research.
PE-22-28 is a synthetic 7-amino-acid peptide corresponding to an active fragment of spadin, an endogenous peptide derived from propeptide processing of the sortilin receptor.
The parent peptide spadin was characterized in research for its selective inhibition of TREK-1 potassium channels.Research on PE-22-28 has focused on its interaction with TREK-1 channels and downstream signaling relevant to antidepressant-pathway models.
Published preclinical studies have examined behavioral endpoints in animal models of depression-related signaling, with comparisons to SSRIs and other pharmacological reference compounds.PE-22-28 is a relatively recent addition to the research-peptide catalog, with growing presence in neuropharmacology-focused research settings.
Research applications
- TREK-1 (KCNK2) potassium channel pharmacology
- Antidepressant-pathway signaling research
- Behavioral neuroscience models (depression-related)
- Sortilin-derived peptide biology
- Comparative research with conventional antidepressants
Technical profile
- Net content
- 10 mg
- Molecular formula
- C35H55N11O9
- Molecular weight
- 773.8947 g/mol
- CAS
- 1801959-12-5
- Sequence
- Gly-Val-Ser-Trp-Gly-Leu-Arg
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
PE-22-28 is a synthetic peptide derived from the spadin family that acts as a selective antagonist of the TREK-1 potassium channel. Research indicates antidepressant-like effects and enhanced neurogenesis in the hippocampus without typical SSRI side effects.
