Cognitive & NeuroprotectiveIn StockCognitive & Neuroprotective
Dihexa
Also known as: N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, PNB-0408
Small synthetic peptide derived from angiotensin IV research; studied in HGF/MET receptor signaling and synaptogenesis research.
Dihexa is a small synthetic peptide derived from research on angiotensin IV, modified with hexanoic-acid residues to enhance blood-brain-barrier penetration and metabolic stability.
It was developed by the Harding laboratory at Washington State University.The published research on Dihexa has focused on its interaction with the hepatocyte growth factor (HGF) / MET receptor system and downstream effects on synaptogenesis (new synapse formation).
Preclinical studies have reported potent effects on synapse formation in cell-culture and animal models of cognitive aging.Dihexa occupies a premium position in the cognitive-peptide research catalog due to synthesis complexity and the relatively specialized research-use case.
Research applications
- HGF/MET receptor system pharmacology
- Synaptogenesis and synaptic-plasticity research
- Angiotensin-IV-derived peptide biology
- Blood-brain-barrier permeability peptide design
- Cognitive-aging preclinical models
Technical profile
- Net content
- 8 mg (30 tablets)
- Molecular formula
- C25H38N4O4
- Molecular weight
- 458.59 g/mol
- CAS
- 1401708-83-5
- Sequence
- N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
Dihexa is a hexapeptide analogue of angiotensin IV with extraordinary potency at the hepatocyte growth factor (HGF) receptor system. It is studied for cognitive enhancement, being approximately 10 million times more potent than BDNF in promoting synaptic connectivity.
