Immune & Anti-InflammatoryIn StockImmune & Anti-Inflammatory
KPV
Also known as: Lys-Pro-Val, α-MSH(11-13)
C-terminal tripeptide of α-MSH with documented anti-inflammatory signaling in preclinical GI and dermatology research.
KPV is the C-terminal tripeptide (Lys-Pro-Val) of α-melanocyte-stimulating hormone (α-MSH).
Despite its small size — just three amino acids — it retains a significant portion of α-MSH's anti-inflammatory signaling profile and has been a focus of anti-inflammatory peptide research for more than two decades.Published research on KPV spans inflammatory-bowel-disease preclinical models, dermatology research (psoriasis, atopic dermatitis models), and NF-κB pathway signaling studies.
It operates through melanocortin-receptor-independent mechanisms at low doses, adding an interesting layer to its pharmacological profile.KPV is often included in multi-peptide blends (KLOW Blend) alongside BPC-157, TB-500, and GHK-Cu for combined research on tissue-repair and inflammation-modulation pathways.
Research applications
- α-MSH-derived anti-inflammatory peptide biology
- NF-κB pathway signaling research
- Inflammatory bowel disease (IBD) preclinical models
- Dermatology and skin-inflammation research
- Small-peptide structure-activity research
Technical profile
- Net content
- 10 mg
- Molecular formula
- C16H30N4O4
- Molecular weight
- 342.43 g/mol
- CAS
- 67727-97-3
- Sequence
- Lys-Pro-Val
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
KPV is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH). It exhibits potent anti-inflammatory activity by inhibiting NF-κB signaling and is studied for applications in inflammatory bowel disease and skin inflammation.
